Sequence Detail

ID/Version

O54992 E9QQ45 Q6QME5 Q6QME6 Q6QME4 Q6QME7 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=MAP kinase-activated protein kinase 5; Short=MAPK-activated protein kinase 5; Short=MAPKAP kinase 5; Short=MAPKAPK-5; EC=2.7.11.1;

Provider

SWISS-PROT

Sequence

Polypeptide 473 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mapkapk5	MAP kinase-activated protein kinase 5	64	98	3	11

Sequence references in MGI

J:45995 Ni H, et al., MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase. Biochem Biophys Res Commun. 1998 Feb 13;243(2):492-6
J:86268 Shi Y, et al., Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination. Mol Cell Biol. 2003 Nov;23(21):7732-41
J:94780 Schumacher S, et al., Scaffolding by ERK3 regulates MK5 in development. EMBO J. 2004 Dec 8;23(24):4770-4779
J:117893 Sun P, et al., PRAK is essential for ras-induced senescence and tumor suppression. Cell. 2007 Jan 26;128(2):295-308
J:180468 Kant S, et al., Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. J Biol Chem. 2006 Nov 17;281(46):35511-9
J:180476 Seternes OM, et al., Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. EMBO J. 2004 Dec 8;23(24):4780-91
J:180541 Zheng M, et al., Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol. 2011 Mar;13(3):263-72
J:180549 Kostenko S, et al., The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor. Cell Mol Life Sci. 2011 Jan;68(2):289-301
J:186303 Gerits N, et al., Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity. Behav Brain Funct. 2007;3:58