Sequence Detail

ID/Version

O55070 Q91X38 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Deoxyribonuclease gamma; Short=DNase gamma; EC=3.1.21.-;AltName: Full=DNase I homolog protein DHP2;AltName: Full=Deoxyribonuclease I-like 3; Short=DNase I-like 3;AltName: Full=Liver and spleen DNase; Short=LS-

Provider

SWISS-PROT

Sequence

Polypeptide 310 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dnase1l3	deoxyribonuclease 1-like 3	22	96	3	13

Sequence references in MGI

J:49550 Baron WF, et al., Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. Gene. 1998 Jul 30;215(2):291-301
J:78618 Shiokawa D, et al., Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells. J Biol Chem. 2002 Aug 23;277(34):31031-7
J:109815 Wilber A, et al., Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice. Clin Exp Immunol. 2003 Oct;134(1):46-52
J:117500 Napirei M, et al., Comparative characterization of rat deoxyribonuclease 1 (Dnase1) and murine deoxyribonuclease 1-like 3 (Dnase1l3). Biochem J. 2005 Jul 15;389(Pt 2):355-64
J:139290 Shiokawa D, et al., Stage-specific expression of DNasegamma during B-cell development and its role in B-cell receptor-mediated apoptosis in WEHI-231 cells. Cell Death Differ. 2007 May;14(5):992-1000
J:147888 Napirei M, et al., Murine serum nucleases--contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3). FEBS J. 2009 Feb;276(4):1059-73
J:211019 Mizuta R, et al., DNase gamma is the effector endonuclease for internucleosomal DNA fragmentation in necrosis. PLoS One. 2013;8(12):e80223
J:234651 Sisirak V, et al., Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity. Cell. 2016 Jun 30;166(1):88-101
J:252490 Jimenez-Alcazar M, et al., Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science. 2017 Dec 1;358(6367):1202-1206