Sequence Detail

ID/Version

O55135 (UniProt | EBI)

Last sequence update: 2000-05-30
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132}; Short=eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132};AltName: Full=B4 integrin interactor;AltName: Full=CAB;AltName: Full=p27(BBP);

Provider

SWISS-PROT

Sequence

Polypeptide 245 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eif6	eukaryotic translation initiation factor 6	36	98	3	14

Sequence references in MGI

J:44335 Biffo S, et al., Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells. J Biol Chem. 1997 Nov 28;272(48):30314-21
J:54867 Wood LC, et al., Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae. J Biol Chem. 1999 Apr 23;274(17):11653-9
J:141257 Gandin V, et al., Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature. 2008 Oct 2;455(7213):684-8
J:171416 Finch AJ, et al., Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev. 2011 May 1;25(9):917-29
J:173559 Miluzio A, et al., Impairment of Cytoplasmic eIF6 Activity Restricts Lymphomagenesis and Tumor Progression without Affecting Normal Growth. Cancer Cell. 2011 Jun 14;19(6):765-75
J:226984 Brina D, et al., eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription. Nat Commun. 2015;6:8261
J:232943 Ricciardi S, et al., Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation. J Thromb Haemost. 2015 Nov;13(11):2108-18
J:277769 Simsek D, et al., The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Cell. 2017 Jun 1;169(6):1051-1065.e18
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89