Sequence Detail

ID/Version

O55143 Q9WUT5 Q9R2A9 (UniProt | EBI)

Last sequence update: 2000-12-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 {ECO:0000305}; Short=SERCA2; Short=SR Ca(2+)-ATPase 2; EC=7.2.2.10 {ECO:0000269|PubMed:28890335};AltName: Full=Calcium pump 2;AltName: Full=Calcium-transporting ATPa

Provider

SWISS-PROT

Sequence

Polypeptide 1044 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	111	137	4	52

Sequence references in MGI

J:59909 Ver Heyen M, et al., Structure and organization of the mouse Atp2a2 gene encoding the sarco(endo)plasmic reticulum Ca2+-ATPase 2 (SERCA2) isoforms. Mamm Genome. 2000 Feb;11(2):159-63
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:149024 Boyd JH, et al., S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res. 2008 May 23;102(10):1239-46
J:153342 Stefanovic B, et al., TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol. 2004 Feb;24(4):1758-68
J:182140 Swift F, et al., Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3997-4001
J:198051 Kim H, et al., Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 2013 Feb 5;17(2):249-60
J:251891 Zhao YG, et al., The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017 Sep 21;67(6):974-989.e6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:301602 Li Y, et al., MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Nat Commun. 2020 Sep 24;11(1):4837
J:319809 Liu B, et al., Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling. Front Pharmacol. 2019;10:1611
J:322371 Senis E, et al., TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Front Cell Dev Biol. 2021;9:747667
J:346110 Yin Y, et al., FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. J Exp Med. 2022 May 2;219(5):e20212491