Sequence Detail

ID/Version

O70131 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Ninjurin-1 {ECO:0000303|PubMed:24347169};AltName: Full=Nerve injury-induced protein 1 {ECO:0000303|PubMed:9465296};Contains: RecName: Full=Secreted ninjurin-1 {ECO:0000305}; AltName: Full=Soluble ninjurin-1 {ECO:0000303|PubMed:32883094};

Provider

SWISS-PROT

Sequence

Polypeptide 152 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ninj1	ninjurin 1	50	100	3	10

Sequence references in MGI

J:45697 Chadwick BP, et al., The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). Genomics. 1998 Jan 1;47(1):58-63
J:169284 Lee HJ, et al., Ninjurin1 mediates macrophage-induced programmed cell death during early ocular development. Cell Death Differ. 2009 Oct;16(10):1395-407
J:197409 Cho SJ, et al., Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9362-7
J:209516 Ahn BJ, et al., Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice. J Biol Chem. 2014 Feb 7;289(6):3328-38
J:212152 Yin GN, et al., Inhibition of Ninjurin 1 restores erectile function through dual angiogenic and neurotrophic effects in the diabetic mouse. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2731-40
J:256932 Yang HJ, et al., Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11500-11505
J:267241 Minoshima A, et al., Pericyte-Specific Ninjurin1 Deletion Attenuates Vessel Maturation and Blood Flow Recovery in Hind Limb Ischemia. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2358-2370
J:268108 Choi S, et al., Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction between Macrophages and Alveolar Epithelial Cells. Sci Rep. 2018 Dec 3;8(1):17542
J:270880 Le H, et al., Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice. Mol Neurobiol. 2017 Nov;54(9):7353-7368
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:294774 Bae SJ, et al., Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts. Exp Mol Med. 2019 Jan 16;51(1):1-16
J:294858 Bae SJ, et al., Ninjurin1 Assembles Into a Homomeric Protein Complex Maintained by N-linked Glycosylation. J Cell Biochem. 2017 Aug;118(8):2219-2230
J:304121 Kayagaki N, et al., NINJ1 mediates plasma membrane rupture during lytic cell death. Nature. 2021 Mar;591(7848):131-136
J:304174 Ahn BJ, et al., Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics. J Biol Chem. 2014 Aug 8;289(32):21926-36
J:304221 Jennewein C, et al., Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation. Am J Respir Cell Mol Biol. 2015 Nov;53(5):656-63
J:304575 Ahn BJ, et al., The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity. Biochem Biophys Res Commun. 2012 Nov 30;428(4):438-44
J:304579 Matsuki M, et al., Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes. Circ J. 2015;79(6):1363-71
J:304581 Shin MW, et al., Ninjurin1 regulates lipopolysaccharide-induced inflammation through direct binding. Int J Oncol. 2016 Feb;48(2):821-8
J:304706 Jeon S, et al., Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis. Circulation. 2020 Nov 3;142(18):1736-1751
J:306000 Kny M, et al., Ninjurin1 regulates striated muscle growth and differentiation. PLoS One. 2019;14(5):e0216987
J:338064 Kayagaki N, et al., Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury. Nature. 2023 Jun;618(7967):1072-1077
J:338065 Degen M, et al., Structural basis of NINJ1-mediated plasma membrane rupture in cell death. Nature. 2023 Jun;618(7967):1065-1071
J:338233 Borges JP, et al., Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death. Elife. 2022 Dec 5;11
J:352389 Dondelinger Y, et al., NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis. Cell Death Dis. 2023 Nov 18;14(11):755
J:352410 Ramos S, et al., NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis. EMBO J. 2024 Apr;43(7):1164-1186