Sequence Detail

ID/Version

O70237 Q3U039 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Zinc finger protein Gfi-1b;AltName: Full=Growth factor independent protein 1B;

Provider

SWISS-PROT

Sequence

Polypeptide 330 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gfi1b	growth factor independent 1B	23	107	3	11

Sequence references in MGI

J:47010 Tong B, et al., The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Mol Cell Biol. 1998 May;18(5):2462-73
J:74523 Saleque S, et al., The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev. 2002 Feb 1;16(3):301-6
J:82015 Doan LL, et al., Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment. J Immunol. 2003 Mar 1;170(5):2356-66
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:141749 Vassen L, et al., Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1. Blood. 2007 Mar 15;109(6):2356-64
J:175166 Saleque S, et al., Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007 Aug 17;27(4):562-72
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89