Sequence Detail

ID/Version

O70326 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Gremlin-1;AltName: Full=Cysteine knot superfamily 1, BMP antagonist 1;AltName: Full=Down-regulated in Mos-transformed cells protein;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 184 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grem1	gremlin 1, DAN family BMP antagonist	86	149	4	22

Sequence references in MGI

J:47309 Hsu DR, et al., The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell. 1998 Apr;1(5):673-83
J:64408 Zhang Q, et al., Cloning of the murine Drm gene (Cktsf1b1) and characterization of its oncogene suppressible promoter. Cytogenet Cell Genet. 2000;89(3-4):242-51
J:84077 Khokha MK, et al., Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet. 2003 Jul;34(3):303-7
J:90991 Michos O, et al., Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development. 2004 Jul;131(14):3401-10
J:91788 Pangas SA, et al., Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin. J Biol Chem. 2004 Jul 30;279(31):32281-6