Sequence Detail

ID/Version

O70348 Q99KD8 (UniProt | EBI)

Last sequence update: 2006-09-19
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Decapping and exoribonuclease protein {ECO:0000303|PubMed:23523372}; Short=DXO {ECO:0000303|PubMed:23523372}; EC=3.6.1.- {ECO:0000269|PubMed:23523372};AltName: Full=5'-3' exoribonuclease DXO {ECO:0000305}; EC=3.1.13.-

Provider

SWISS-PROT

Sequence

Polypeptide 397 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dxo	decapping exoribonuclease	24	96	3	2

Sequence references in MGI

J:86796 Xie T, et al., Analysis of the gene-dense Major Histocompatibility Complex class III region and its comparison to mouse. Genome Res. 2003 Dec;13(12):2621-36
J:196446 Jiao X, et al., A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol Cell. 2013 Apr 11;50(1):104-15
J:279925 Yun JS, et al., Molecular mechanism for the inhibition of DXO by adenosine 3',5'-bisphosphate. Biochem Biophys Res Commun. 2018 Sep 26;504(1):89-95
J:279953 Jiao X, et al., 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Cell. 2017 Mar 9;168(6):1015-1027.e10
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306600 Doamekpor SK, et al., DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs. Nucleic Acids Res. 2020 Jun 19;48(11):6136-6148
J:306601 Sharma S, et al., Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. Nucleic Acids Res. 2020 Jul 9;48(12):6788-6798