Sequence Detail

ID/Version

O70373 (UniProt | EBI)

Last sequence update: 2005-04-12
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Xin actin-binding repeat-containing protein 1;AltName: Full=Cardiomyopathy-associated protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 1129 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Xirp1	xin actin-binding repeat containing 1	20	105	3	3

Sequence references in MGI

J:52598 Wang DZ, et al., Requirement of a novel gene, Xin, in cardiac morphogenesis. Development. 1999 Mar;126(6):1281-94
J:78855 Sinn HW, et al., Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev Dyn. 2002 Sep;225(1):1-13
J:129033 Choi S, et al., The intercalated disc protein, mXinalpha, is capable of interacting with beta-catenin and bundling actin filaments. J Biol Chem. 2007 Dec 7;282(49):36024-36
J:132079 Gustafson-Wagner EA, et al., Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2680-92
J:140126 Grosskurth SE, et al., Emergence of Xin demarcates a key innovation in heart evolution. PLoS One. 2008;3(8):e2857
J:206707 Wang Q, et al., Intercalated disc protein, mXinalpha, suppresses p120-catenin-induced branching phenotype via its interactions with p120-catenin and cortactin. Arch Biochem Biophys. 2013 Jul 1;535(1):91-100
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:347337 Al-Sajee D, et al., Xin-deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality. Acta Physiol (Oxf). 2015 Jun;214(2):248-60