Sequence Detail

ID/Version

O70582 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Arachidonate 12-lipoxygenase, 12R-type {ECO:0000305}; Short=12R-LOX; Short=12R-lipoxygenase; EC=1.13.11.- {ECO:0000269|PubMed:10100631, ECO:0000269|PubMed:11256953, ECO:0000269|PubMed:16129665};AltName: Full=Epidermis

Provider

SWISS-PROT

Sequence

Polypeptide 701 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alox12b	arachidonate 12-lipoxygenase, 12R type	45	102	3	6

Sequence references in MGI

J:46510 Krieg P, et al., Murine 12(R)-lipoxygenase: functional expression, genomic structure and chromosomal localization. FEBS Lett. 1999 Mar 5;446(1):142-8
J:46809 Krieg P, et al., cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. Biochim Biophys Acta. 1998 Mar 6;1391(1):7-12
J:51421 Sun D, et al., Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment. J Biol Chem. 1998 Dec 11;273(50):33540-7
J:102904 Meruvu S, et al., Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis. J Biol Chem. 2005 Nov 4;280(44):36633-41
J:119554 Moran JL, et al., A mouse mutation in the 12R-Lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier. J Invest Dermatol. 2007 Aug;127(8):1893-7
J:134709 Epp N, et al., 12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol. 2007 Apr 9;177(1):173-82
J:174794 Zheng Y, et al., Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope. J Biol Chem. 2011 Jul 8;286(27):24046-56
J:276497 Siebert M, et al., Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes. Biochem J. 2001 Apr 1;355(Pt 1):97-104