Sequence Detail

ID/Version

O88273 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Gremlin-2;AltName: Full=Cysteine knot superfamily 1, BMP antagonist 2;AltName: Full=Protein related to DAN and cerberus; Short=PRDC;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 168 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grem2	gremlin 2, DAN family BMP antagonist	16	105	4	14

Sequence references in MGI

J:48401 Minabe-Saegusa C, et al., Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. Dev Growth Differ. 1998 Jun;40(3):343-53
J:117670 Sudo S, et al., Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J Biol Chem. 2004 May 28;279(22):23134-41
J:200257 Kattamuri C, et al., Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers. J Mol Biol. 2012 Dec 14;424(5):313-27
J:205025 Nolan K, et al., Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism. Structure. 2013 Aug 6;21(8):1417-29