Sequence Detail

ID/Version

O88351 Q9R1J6 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Inhibitor of nuclear factor kappa-B kinase subunit beta; Short=I-kappa-B-kinase beta; Short=IKK-B; Short=IKK-beta; Short=IkBKB; EC=2.7.11.10 {ECO:0000250|UniProtKB:O14920};AltName: Full=I-kappa-B kinas

Provider

SWISS-PROT

Sequence

Polypeptide 757 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ikbkb	inhibitor of kappaB kinase beta	102	101	3	23

Sequence references in MGI

J:54323 Li Q, et al., Severe liver degeneration in mice lacking the IkappaB kinase 2 gene [see comments]. Science. 1999 Apr 9;284(5412):321-5
J:54768 Nakano H, et al., Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3537-42
J:55680 Tanaka M, et al., Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity. 1999 Apr;10(4):421-9
J:58020 Hu MC, et al., Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkappaB kinases (IKK-alpha/beta) and IKK-beta is a developmentally regulated protein kinase. Oncogene. 1999 Sep 30;18(40):5514-24
J:60875 Jobin C, et al., The IkappaB/NF-kappaB system: a key determinant of mucosal inflammation and protection. Am J Physiol Cell Physiol. 2000 Mar;278(3):C451-62
J:163158 Teo H, et al., Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol. 2010 Aug;12(8):758-67
J:179016 Iwasaki H, et al., The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat Immunol. 2011 Dec;12(12):1167-75
J:216669 Ren J, et al., IKKbeta is an IRF5 kinase that instigates inflammation. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17438-43
J:275558 Dondelinger Y, et al., Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. Nat Commun. 2019 Apr 15;10(1):1729
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89