Sequence Detail

ID/Version

O88470 Q8K3X9 (UniProt | EBI)

Last sequence update: 2005-03-15
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Forkhead box protein L2;AltName: Full=Pituitary forkhead factor; Short=P-Frk;

Provider

SWISS-PROT

Sequence

Polypeptide 375 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Foxl2	forkhead box L2	58	182	4	13

Sequence references in MGI

J:48144 Treier M, et al., Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
J:80839 Cocquet J, et al., Evolution and expression of FOXL2. J Med Genet. 2002 Dec;39(12):916-21
J:90743 Pisarska MD, et al., Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene. Endocrinology. 2004 Jul;145(7):3424-33
J:99790 Ottolenghi C, et al., Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet. 2005 Jul 15;14(14):2053-62
J:114729 Lee K, et al., Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. Biochem Biophys Res Commun. 2005 Oct 28;336(3):876-81
J:148556 Blount AL, et al., FoxL2 and Smad3 coordinately regulate follistatin gene transcription. J Biol Chem. 2009 Mar 20;284(12):7631-45
J:157008 Uhlenhaut NH, et al., Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell. 2009 Dec 11;139(6):1130-42
J:157316 Kim SY, et al., Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha. Endocrinology. 2009 Nov;150(11):5085-93