Sequence Detail

ID/Version

O88495 Q3V1S8 (UniProt | EBI)

Last sequence update: 2013-10-16
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Melatonin-related receptor;AltName: Full=G protein-coupled receptor 50;AltName: Full=H9;

Provider

SWISS-PROT

Sequence

Polypeptide 591 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gpr50	G-protein-coupled receptor 50	11	105	2	8

Sequence references in MGI

J:52873 Gubitz AK, et al., Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). Genomics. 1999 Jan 15;55(2):248-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131227 Ivanova EA, et al., Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse. Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E176-82
J:176354 Li J, et al., GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling. PLoS One. 2011;6(8):e23725
J:265743 Wojciech S, et al., The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development. Nat Commun. 2018 Mar 23;9(1):1216
J:317545 Ma YX, et al., G protein coupled receptor 50 promotes self-renewal and neuronal differentiation of embryonic neural progenitor cells through regulation of notch and wnt/beta-catenin signalings. Biochem Biophys Res Commun. 2015 Mar 20;458(4):836-42