Sequence Detail

ID/Version

O88554 Q99N29 (UniProt | EBI)

Last sequence update: 2001-09-26
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Poly [ADP-ribose] polymerase 2; Short=PARP-2; Short=mPARP-2; EC=2.4.2.30 {ECO:0000269|PubMed:12065591};AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 2; Short=ARTD2;AltName: Full=DNA ADP-ribosyltra

Provider

SWISS-PROT

Sequence

Polypeptide 559 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Parp2	poly (ADP-ribose) polymerase family, member 2	68	100	3	27

Sequence references in MGI

J:54433 Berghammer H, et al., pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. FEBS Lett. 1999 Apr 23;449(2-3):259-63
J:55622 Ame JC, et al., PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem. 1999 Jun 18;274(25):17860-8
J:68799 Ame JC, et al., A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. structure and expression of the mouse PARP-2 gene. J Biol Chem. 2001 Apr 6;276(14):11092-9
J:77259 Schreiber V, et al., Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem. 2002 Jun 21;277(25):23028-36
J:78954 Benchoua A, et al., Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2. J Biol Chem. 2002 Sep 13;277(37):34217-22
J:83371 Menissier de Murcia J, et al., Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J. 2003 May 1;22(9):2255-63
J:311744 Kelleher AM, et al., Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2109252118