Sequence Detail

ID/Version

O88705 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3;AltName: Full=Hyperpolarization-activated cation channel 3; Short=HAC-3;

Provider

SWISS-PROT

Sequence

Polypeptide 779 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hcn3	hyperpolarization-activated, cyclic nucleotide-gated K+ 3	33	108	3	6

Sequence references in MGI

J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
J:48083 Ludwig A, et al., A family of hyperpolarization-activated mammalian cation channels. Nature. 1998 Jun 11;393(6685):587-91
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100888 Mistrik P, et al., The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. J Biol Chem. 2005 Jul 22;280(29):27056-61
J:188823 Fenske S, et al., HCN3 contributes to the ventricular action potential waveform in the murine heart. Circ Res. 2011 Oct 14;109(9):1015-23
J:203510 Cao-Ehlker X, et al., Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). J Biol Chem. 2013 Mar 15;288(11):7580-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302875 Lainez S, et al., HCN3 ion channels: roles in sensory neuronal excitability and pain. J Physiol. 2019 Sep;597(17):4661-4675