Sequence Detail

ID/Version

O88839 Q3UE21 A4ZYV2 Q9QYL2 Q3U7C2 Q8C7Z0 Q91VS9 Q3TDN7 (UniProt | EBI)

Last sequence update: 2003-11-14
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Disintegrin and metalloproteinase domain-containing protein 15; Short=ADAM 15; EC=3.4.24.-;AltName: Full=AD56;AltName: Full=Metalloprotease RGD disintegrin protein;AltName: Full=Metalloproteinase-like, disintegrin-like, and c

Provider

SWISS-PROT

Sequence

Polypeptide 864 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adam15	ADAM metallopeptidase domain 15	49	98	3	9

Sequence references in MGI

J:50328 Lum L, et al., Intracellular maturation of the mouse metalloprotease disintegrin MDC15. J Biol Chem. 1998 Oct 2;273(40):26236-47
J:76537 Eto K, et al., Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem. 2002 May 17;277(20):17804-10
J:84800 Horiuchi K, et al., Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol. 2003 Aug;23(16):5614-24
J:85987 Shimizu E, et al., Structure and expression of the murine ADAM 15 gene and its splice variants, and difference of interaction between their cytoplasmic domains and Src family proteins. Biochem Biophys Res Commun. 2003 Oct 3;309(4):779-85
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112508 Bohm BB, et al., Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. Arthritis Rheum. 2005 Apr;52(4):1100-9
J:113785 Howard L, et al., Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. J Biol Chem. 1999 Oct 29;274(44):31693-9
J:138010 Xie B, et al., An Adam15 amplification loop promotes vascular endothelial growth factor-induced ocular neovascularization. FASEB J. 2008 Aug;22(8):2775-83
J:145667 Pasten-Hidalgo K, et al., Presence, processing, and localization of mouse ADAM15 during sperm maturation and the role of its disintegrin domain during sperm-egg binding. Reproduction. 2008 Jul;136(1):41-51