Sequence Detail

ID/Version

O88890 A2ANL8 Q9QWV6 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=SH2 domain-containing protein 1A;AltName: Full=Signaling lymphocytic activation molecule-associated protein; Short=SLAM-associated protein;AltName: Full=T-cell signal transduction molecule SAP;

Provider

SWISS-PROT

Sequence

Polypeptide 126 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sh2d1a	SH2 domain containing 1A	19	97	4	15

Sequence references in MGI

J:50127 Sayos J, et al., The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM [see comments]. Nature. 1998 Oct 1;395(6701):462-9
J:64014 Wu C, et al., Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease. Immunogenetics. 2000 Aug;51(10):805-15
J:109313 Latour S, et al., Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat Cell Biol. 2003 Feb;5(2):149-54
J:151768 Dong Z, et al., Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Nat Immunol. 2009 Sep;10(9):973-80
J:166054 Wang N, et al., Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse. J Immunol. 2010 Nov 15;185(10):5683-7
J:187430 Dong Z, et al., The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity. 2012 Jun 29;36(6):974-85