Sequence Detail

ID/Version

O88895 O88896 Q3UM33 (UniProt | EBI)

Last sequence update: 2022-02-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Histone deacetylase 3 {ECO:0000305}; Short=HD3; EC=3.5.1.98 {ECO:0000305|PubMed:23911289, ECO:0000305|PubMed:30279482};AltName: Full=Protein deacetylase HDAC3; EC=3.5.1.- {ECO:0000250|UniProtKB:O15379};AltName: Full=P

Provider

SWISS-PROT

Sequence

Polypeptide 428 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hdac3	histone deacetylase 3	137	123	3	23

Sequence references in MGI

J:57850 Mahlknecht U, et al., Cloning and characterization of the murine histone deacetylase (HDAC3). Biochem Biophys Res Commun. 1999 Sep 24;263(2):482-90
J:67665 Zhang CL, et al., Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001 Jan 5;276(1):35-9
J:97578 Mejat A, et al., Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression. Nat Neurosci. 2005 Mar;8(3):313-21
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104117 Kim SC, et al., Kruppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1). Nucleic Acids Res. 2005;33(21):6805-15
J:104339 Li X, et al., Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science. 2002 Aug 16;297(5584):1180-3
J:106935 Davis CA, et al., PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol. 2006 Apr;26(7):2626-36
J:142342 Alenghat T, et al., Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature. 2008 Dec 18;456(7224):997-1000
J:158064 Gupta P, et al., HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. PLoS One. 2009;4(2):e4363
J:166802 Yan W, et al., Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. J Biol Chem. 2010 Oct 8;285(41):31418-26
J:229252 Okuda H, et al., A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis. PLoS One. 2015;10(4):e0124293
J:240095 Shi G, et al., Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep. 2016 Feb 02;14(4):823-34
J:271411 Deliu E, et al., Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. Nat Neurosci. 2018 Dec;21(12):1717-1727
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319948 Kelly RDW, et al., Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. Sci Rep. 2018 Oct 2;8(1):14690