Sequence Detail

ID/Version

O88907 Q8C6H5 (UniProt | EBI)

Last sequence update: 2004-12-07
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=E3 SUMO-protein ligase PIAS1; EC=2.3.2.27;AltName: Full=DEAD/H box-binding protein 1;AltName: Full=Protein inhibitor of activated STAT protein 1;AltName: Full=RING-type E3 ubiquitin transferase PIAS1 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 651 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pias1	protein inhibitor of activated STAT 1	62	111	4	18

Sequence references in MGI

J:55317 Liu B, et al., Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10626-31
J:63546 Sturm S, et al., Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons. J Mol Neurosci. 2000 Feb-Apr;14(1-2):107-21
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107295 Lee H, et al., PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein. Genes Dev. 2006 Apr 1;20(7):784-94
J:130070 Siatecka M, et al., Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. Mol Cell Biol. 2007 Dec;27(24):8547-60
J:196239 Rabellino A, et al., The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. Cancer Res. 2012 May 1;72(9):2275-84
J:219047 Liu Y, et al., Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein beta (C/EBPbeta) during adipogenesis. Mol Cell Biol. 2013 Nov;33(22):4606-17
J:245382 Park SW, et al., SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Nat Struct Mol Biol. 2007 Jan;14(1):68-75
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89