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Sequence Detail
ID/Version
O88962 Q9R217 (UniProt | EBI) Last sequence update: 1998-11-01
Last annotation update: 2024-07-24
Sequence
description
from provider
RecName: Full=7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; EC=1.14.14.139 {ECO:0000250|UniProtKB:O02766};AltName: Full=7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase;AltName: Full=CYPVIIIB1;AltName: Full=Cytochrome P450 8B1;AltN
Provider SWISS-PROT
Sequence
Polypeptide 500 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 12 99 5 10
Sequence references in MGI J:53496 Gafvels M, et al., Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 1;56(2):184-96
J:100206 Li-Hawkins J, et al., Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest. 2002 Oct;110(8):1191-200
J:247076 Bertaggia E, et al., Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption. Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E121-E133
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory