Sequence Detail

ID/Version

O88962 Q9R217 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; EC=1.14.14.139 {ECO:0000250|UniProtKB:O02766};AltName: Full=7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase;AltName: Full=CYPVIIIB1;AltName: Full=Cytochrome P450 8B1;AltN

Provider

SWISS-PROT

Sequence

Polypeptide 500 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	12	99	5	10

Sequence references in MGI

J:53496 Gafvels M, et al., Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 1;56(2):184-96
J:100206 Li-Hawkins J, et al., Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest. 2002 Oct;110(8):1191-200
J:247076 Bertaggia E, et al., Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption. Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E121-E133
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89