ID/Version |
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Sequence description from provider |
RecName: Full=7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; EC=1.14.14.139 {ECO:0000250|UniProtKB:O02766};AltName: Full=7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase;AltName: Full=CYPVIIIB1;AltName: Full=Cytochrome P450 8B1;AltN | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
500
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:53496
Gafvels M, et al., Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 1;56(2):184-96
J:100206 Li-Hawkins J, et al., Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest. 2002 Oct;110(8):1191-200 J:247076 Bertaggia E, et al., Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption. Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E121-E133 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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