Sequence Detail

ID/Version

O89017 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Legumain {ECO:0000303|PubMed:9742219}; EC=3.4.22.34 {ECO:0000269|PubMed:24407422, ECO:0000269|PubMed:9742219, ECO:0000269|PubMed:9891971};AltName: Full=Protease, cysteine 1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 435 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lgmn	legumain	57	101	3	28

Sequence references in MGI

J:50324 Chen JM, et al., Cloning and expression of mouse legumain, a lysosomal endopeptidase. Biochem J. 1998 Oct 1;335(Pt 1):111-7
J:50855 Halfon S, et al., Autocatalytic activation of human legumain at aspartic acid residues. FEBS Lett. 1998 Oct 30;438(1-2):114-8
J:121440 Morita Y, et al., Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells. FEBS Lett. 2007 Apr 3;581(7):1417-24
J:172774 Miller G, et al., Asparagine endopeptidase is required for normal kidney physiology and homeostasis. FASEB J. 2011 May;25(5):1606-17
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:337206 Rodriguez-Silvestre P, et al., Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells. Science. 2023 Jun 23;380(6651):1258-1265