Sequence Detail

ID/Version

O89110 O35669 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Caspase-8 {ECO:0000303|PubMed:9654089, ECO:0000303|PubMed:9837723}; Short=CASP-8 {ECO:0000303|PubMed:9654089, ECO:0000303|PubMed:9837723}; EC=3.4.22.61 {ECO:0000269|PubMed:12065591, ECO:0000269|PubMed:32971525, ECO:0000269|Pu

Provider

SWISS-PROT

Sequence

Polypeptide 480 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Casp8	caspase 8	117	122	3	38

Sequence references in MGI

J:47358 Sakamaki K, et al., Molecular cloning and characterization of mouse caspase-8. Eur J Biochem. 1998 Apr 15;253(2):399-405
J:49459 Varfolomeev EE, et al., Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity. 1998 Aug;9(2):267-76
J:51525 Van de Craen M, et al., Molecular cloning and identification of murine caspase-8. J Mol Biol. 1998 Dec 11;284(4):1017-26
J:78954 Benchoua A, et al., Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2. J Biol Chem. 2002 Sep 13;277(37):34217-22
J:139785 Sun H, et al., TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell. 2008 May 2;133(3):415-26
J:196105 Milovic-Holm K, et al., FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. EMBO J. 2007 Jan 24;26(2):391-401
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:214393 Dillon CP, et al., RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell. 2014 May 22;157(5):1189-202
J:214394 Rickard JA, et al., RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell. 2014 May 22;157(5):1175-88
J:217283 Nam YJ, et al., Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Mol Cell. 2004 Sep 24;15(6):901-12
J:265780 Meng H, et al., Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2001-E2009
J:267270 Sarhan J, et al., Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10888-E10897
J:268622 Orning P, et al., Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science. 2018 Nov 30;362(6418):1064-1069
J:279494 Tang Y, et al., K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019 Sep 13;10(1):4157
J:281456 Newton K, et al., Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019 Oct;574(7778):428-431
J:285930 Fritsch M, et al., Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature. 2019 Nov;575(7784):683-687
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297419 Gitlin AD, et al., Integration of innate immune signalling by caspase-8 cleavage of N4BP1. Nature. 2020 Nov;587(7833):275-280
J:300952 Muendlein HI, et al., ZBP1 promotes LPS-induced cell death and IL-1beta release via RHIM-mediated interactions with RIPK1. Nat Commun. 2021 Jan 4;12(1):86