Sequence Detail

ID/Version

P01872 P01873 (UniProt | EBI)

Last sequence update: 2005-02-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Immunoglobulin heavy constant mu;Contains: RecName: Full=Mu' chain {ECO:0000303|PubMed:29323348}; AltName: Full=55 kDa mu' chain {ECO:0000305|PubMed:29323348};

Provider

SWISS-PROT

Sequence

Polypeptide 454 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ighm	immunoglobulin heavy constant mu	52	102	2	41

Sequence references in MGI

J:6483 Auffray C, et al., Nucleotide sequence of a cloned cDNA corresponding to secreted mu chain of mouse immunoglobulin. Gene. 1980 Dec;12(1-2):77-86
J:30481 Kawakami T, et al., Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes. Nucleic Acids Res. 1980 Sep 11;8(17):3933-45
J:63487 Baumgarth N, et al., B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med. 2000 Jul 17;192(2):271-80
J:64298 Kitamura D, et al., Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion [see comments]. Nature. 1992 Mar 12;356(6365):154-6
J:65462 Shibuya A, et al., Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. Nat Immunol. 2000 Nov;1(5):441-6
J:70398 Kitamura D, et al., A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 1991 Apr 4;350(6317):423-6
J:240689 Nguyen TT, et al., The IgM receptor FcmuR limits tonic BCR signaling by regulating expression of the IgM BCR. Nat Immunol. 2017 Mar;18(3):321-333
J:260156 Klaus T, et al., Mouse Antibody of IgM Class is Prone to Non-Enzymatic Cleavage between CH1 and CH2 Domains. Sci Rep. 2018 Jan 11;8(1):519
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:340662 Rochereau N, et al., Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis. Cell Rep. 2021 Nov 16;37(7):110006