Sequence Detail

ID/Version

P04351 Q791T3 P97945 (UniProt | EBI)

Last sequence update: 1987-03-20
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Interleukin-2; Short=IL-2;AltName: Full=T-cell growth factor; Short=TCGF;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 169 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il2	interleukin 2	66	103	2	28

Sequence references in MGI

J:3450 Matesanz F, et al., A new cDNA sequence for the murine interleukin-2 gene. Biochim Biophys Acta. 1992 Oct 20;1132(3):335-6
J:7697 Fuse A, et al., Organization and structure of the mouse interleukin-2 gene. Nucleic Acids Res. 1984 Dec 21;12(24):9323-31
J:7721 Kashima N, et al., Unique structure of murine interleukin-2 as deduced from cloned cDNAs. Nature. 1985 Jan 31-Feb 6;313(6001):402-4
J:16175 Zurawski SM, et al., Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. EMBO J. 1993 Dec 15;12(13):5113-9
J:19325 Yokota T, et al., Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. Proc Natl Acad Sci U S A. 1985 Jan;82(1):68-72
J:43385 Matesanz F, et al., Existence of at least five interleukin-2 molecules in different mouse strains. Immunogenetics. 1993;38(4):300-3
J:61763 Lyons PA, et al., Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Genome Res. 2000 Apr;10(4):446-53
J:113077 Reya T, et al., Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. Dev Immunol. 1998;5(4):287-302
J:229742 Spangler JB, et al., Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity. 2015 May 19;42(5):815-25
J:327791 Smith GA, et al., Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May;12(5):373-9