Sequence Detail

ID/Version

P05480 F8WI90 Q2M4I4 (UniProt | EBI)

Last sequence update: 2021-02-10
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Proto-oncogene tyrosine-protein kinase Src {ECO:0000305}; EC=2.7.10.2 {ECO:0000269|PubMed:8910389};AltName: Full=Proto-oncogene c-Src;AltName: Full=pp60c-src; Short=p60-Src;

Provider

SWISS-PROT

Sequence

Polypeptide 535 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Src	Rous sarcoma oncogene	294	113	3	79

Sequence references in MGI

J:32617 Martinez R, et al., Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart. Science. 1987 Jul 24;237(4813):411-5
J:43680 Cirri P, et al., c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells. Biochem Biophys Res Commun. 1997 Oct 20;239(2):493-7
J:51174 Brown MT, et al., ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol Cell Biol. 1998 Dec;18(12):7038-51
J:86831 Avrov K, et al., The role of c-Src in platelet-derived growth factor alpha receptor internalization. Exp Cell Res. 2003 Dec 10;291(2):426-34
J:89495 Miyazaki T, et al., Src kinase activity is essential for osteoclast function. J Biol Chem. 2004 Apr 23;279(17):17660-6
J:118143 Kostenko EV, et al., Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Mol Cell Biol. 2006 Dec;26(23):8964-75
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:145752 Luan B, et al., Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature. 2009 Feb 26;457(7233):1146-9
J:177164 Vindis C, et al., EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J Cell Biol. 2003 Aug 18;162(4):661-71
J:182942 Kuroiwa M, et al., The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation. J Cell Sci. 2011 May 15;124(Pt 10):1726-38
J:188792 Sun G, et al., Protein tyrosine phosphatase alpha phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions. Mol Cell Biol. 2012 Sep;32(18):3776-89
J:219844 Taniguchi K, et al., A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 5;519(7541):57-62
J:281184 Miyazaki T, et al., Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J Cell Biol. 2003 Mar 3;160(5):709-18
J:281199 Rodriguez-Fernandez JL, et al., Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase. J Biol Chem. 1996 Nov 1;271(44):27895-901
J:283622 Wang L, et al., Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science. 2019 Aug 16;365(6454)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89