Sequence Detail

ID/Version

P05532 Q61416 Q61415 Q6QJB7 Q7TS86 Q61417 Q6LEE9 Q6QJB8 Q8C8K9 (UniProt | EBI)

Last sequence update: 2011-10-19
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Mast/stem cell growth factor receptor Kit; Short=SCFR; EC=2.7.10.1;AltName: Full=Proto-oncogene c-Kit;AltName: Full=Tyrosine-protein kinase Kit;AltName: CD_antigen=CD117;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 979 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kit	KIT proto-oncogene receptor tyrosine kinase	204	229	4	190

Sequence references in MGI

J:1508 Rossi P, et al., A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids. Dev Biol. 1992 Jul;152(1):203-7
J:4320 Yasuda H, et al., Cloning and functional analysis of the mouse c-kit promoter. Biochem Biophys Res Commun. 1993 Mar 31;191(3):893-901
J:9280 Qiu FH, et al., Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO J. 1988 Apr;7(4):1003-11
J:10187 Tan JC, et al., The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase. Science. 1990 Jan 12;247(4939):209-12
J:10528 Nocka K, et al., Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J. 1990 Jun;9(6):1805-13
J:27510 Reith AD, et al., Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J. 1991 Sep;10(9):2451-9
J:91867 Hayashi S, et al., Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse. Nucleic Acids Res. 1991 Mar 25;19(6):1267-71
J:96391 Ruan HB, et al., Identification of a Novel Point Mutation of Mouse Proto-Oncogene c-kit Through N-Ethyl-N-nitrosourea Mutagenesis. Genetics. 2005 Feb;169(2):819-31
J:142551 Samayawardhena LA, et al., Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem. 2008 Oct 24;283(43):29175-85
J:160247 Drube S, et al., The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells. Blood. 2010 May 13;115(19):3899-906
J:167633 Chen S, et al., Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase. Am J Pathol. 2010 Dec;177(6):3125-32
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89