Sequence Detail

ID/Version

P05555 Q8CA73 (UniProt | EBI)

Last sequence update: 1991-02-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Integrin alpha-M;AltName: Full=CD11 antigen-like family member B;AltName: Full=CR-3 alpha chain;AltName: Full=Cell surface glycoprotein MAC-1 subunit alpha;AltName: Full=Leukocyte adhesion receptor MO1;AltName: CD_antigen=CD11b;Flags: Precur

Provider

SWISS-PROT

Sequence

Polypeptide 1153 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itgam	integrin alpha M	61	114	3	16

Sequence references in MGI

J:8378 Sastre L, et al., A partial genomic DNA clone for the alpha subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1. Proc Natl Acad Sci U S A. 1986 Aug;83(15):5644-8
J:9306 Pytela R, Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor. EMBO J. 1988 May;7(5):1371-8
J:38052 Coxon A, et al., A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996 Dec;5(6):653-66
J:41751 Dong ZM, et al., A new class of obesity genes encodes leukocyte adhesion receptors. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7526-30
J:44403 Tang T, et al., A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J Exp Med. 1997 Dec 1;186(11):1853-63
J:52128 Rosenkranz AR, et al., Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice. J Immunol. 1998 Dec 15;161(12):6463-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:140167 Wakselman S, et al., Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. J Neurosci. 2008 Aug 6;28(32):8138-43
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89