Sequence Detail

ID/Version

P06240 Q91X65 Q62320 Q61794 Q61795 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Proto-oncogene tyrosine-protein kinase LCK; EC=2.7.10.2;AltName: Full=Leukocyte C-terminal Src kinase; Short=LSK;AltName: Full=Lymphocyte cell-specific protein-tyrosine kinase;AltName: Full=p56-LCK;

Provider

SWISS-PROT

Sequence

Polypeptide 509 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lck	lymphocyte protein tyrosine kinase	94	100	3	44

Sequence references in MGI

J:1119 Molina TJ, et al., Profound block in thymocyte development in mice lacking p56lck [see comments]. Nature. 1992 May 14;357(6374):161-4
J:8130 Marth JD, et al., A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell. 1985 Dec;43(2 Pt 1):393-404
J:9539 Garvin AM, et al., Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line. Mol Cell Biol. 1988 Aug;8(8):3058-64
J:29565 Voronova AF, et al., Two lck transcripts containing different 5' untranslated regions are present in T cells. Mol Cell Biol. 1987 Dec;7(12):4407-13
J:30046 Voronova AF, et al., Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion. Nature. 1986 Feb 20-26;319(6055):682-5
J:76896 Bachmaier K, et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000 Jan 13;403(6766):211-6
J:88309 Abraham KM, et al., Thymic tumorigenesis induced by overexpression of p56lck. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3977-81
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112254 Yasuda K, et al., Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol. 2002 Sep 15;169(6):2813-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89