Sequence Detail

ID/Version

P06802 Q924C4 Q542E9 (UniProt | EBI)

Last sequence update: 2002-09-19
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; Short=E-NPP 1;AltName: Full=Alkaline phosphodiesterase I; EC=3.1.4.1 {ECO:0000269|PubMed:11027689, ECO:0000269|PubMed:1647027, ECO:0000269|PubMed:23027977, ECO

Provider

SWISS-PROT

Sequence

Polypeptide 906 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Enpp1	ectonucleotide pyrophosphatase/phosphodiesterase 1	281	102	3	16

Sequence references in MGI

J:8145 van Driel IR, et al., Murine plasma cell membrane antigen PC-1: molecular cloning of cDNA and analysis of expression. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8619-23
J:10767 Buckley MF, et al., Plasma cell membrane glycoprotein PC-1. cDNA cloning of the human molecule, amino acid sequence, and chromosomal location. J Biol Chem. 1990 Oct 15;265(29):17506-11
J:19267 Rebbe NF, et al., Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity associated with the mouse plasma cell differentiation antigen PC-1. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5192-6
J:21444 van Driel IR, et al., Plasma cell membrane glycoprotein PC-1. Primary structure deduced from cDNA clones. J Biol Chem. 1987 Apr 5;262(10):4882-7
J:48527 Okawa A, et al., Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet. 1998 Jul;19(3):271-3
J:66908 Gijsbers R, et al., Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases. J Biol Chem. 2001 Jan 12;276(2):1361-8
J:77731 Hessle L, et al., Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9445-9
J:78186 Banakh I, et al., Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodies. Eur J Immunogenet. 2002 Aug;29(4):307-13
J:83030 Gijsbers R, et al., Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1. Biochem J. 2003 Apr 15;371(Pt 2):321-30
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:133038 Belli SI, et al., Identification and characterization of a soluble form of the plasma cell membrane glycoprotein PC-1 (5'-nucleotide phosphodiesterase). Eur J Biochem. 1993 Oct 1;217(1):421-8
J:168664 Babij P, et al., New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification. J Bone Miner Res. 2009 Sep;24(9):1552-64
J:190295 Kato K, et al., Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16876-81
J:215824 Li Q, et al., Spontaneous asj-2J mutant mouse as a model for generalized arterial calcification of infancy: a large deletion/insertion mutation in the Enpp1 gene. PLoS One. 2014;9(12):e113542
J:218042 Hajjawi MO, et al., Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1(-/-) mice. Bone. 2014 Dec;69:139-47
J:247392 Jansen S, et al., Structure of NPP1, an ectonucleotide pyrophosphatase/phosphodiesterase involved in tissue calcification. Structure. 2012 Nov 07;20(11):1948-59
J:266558 Jin Y, et al., Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling. Development. 2018 Sep 20;145(18):dev164830
J:273505 Kato K, et al., Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nat Commun. 2018 Oct 24;9(1):4424
J:273512 Li L, et al., Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 2014 Dec;10(12):1043-8
J:273580 Bertrand J, et al., Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice. Ann Rheum Dis. 2012 Jul;71(7):1249-53
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89