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Sequence Detail
ID/Version
P07750 (UniProt | EBI) Last sequence update: 1988-08-01
Last annotation update: 2024-07-24
Sequence
description
from provider
RecName: Full=Interleukin-4; Short=IL-4;AltName: Full=B-cell IgG differentiation factor;AltName: Full=B-cell growth factor 1;AltName: Full=B-cell stimulatory factor 1; Short=BSF-1;AltName: Full=IGG1 induction factor;AltName: Full=Lymphocyt
Provider SWISS-PROT
Sequence
Polypeptide 140 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Il4 interleukin 4 108 110 3 29
Sequence references in MGI J:8210 Noma Y, et al., Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Nature. 1986 Feb 20-26;319(6055):640-6
J:8249 Lee F, et al., Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2061-5
J:8612 Otsuka T, et al., Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities. Nucleic Acids Res. 1987 Jan 12;15(1):333-44
J:31932 Kaplan MH, et al., Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 1996 Mar;4(3):313-9
J:52881 Sideras P, et al., IgG1 induction factor: a single molecular entity with multiple biological functions. Adv Exp Med Biol. 1987;213:227-36
J:227653 Terawaki S, et al., RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4. J Cell Biol. 2015 Sep 28;210(7):1133-52
J:244446 Edukulla R, et al., Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression. J Biol Chem. 2015 May 22;290(21):13510-20
J:252702 Brombacher TM, et al., IL-13-Mediated Regulation of Learning and Memory. J Immunol. 2017 Apr 01;198(7):2681-2688

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory