Sequence Detail

ID/Version

P07978 (UniProt | EBI)

Last sequence update: 1988-08-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protamine-2;AltName: Full=Sperm histone P2;AltName: Full=Sperm protamine P2;Contains: RecName: Full=PP2-A;Contains: RecName: Full=PP2-C;Contains: RecName: Full=PP2-D;Contains: RecName: Full=PP2-B; AltName: Full=Protamine mP2 {ECO:000030

Provider

SWISS-PROT

Sequence

Polypeptide 107 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prm2	protamine 2	19	100	2	6

Sequence references in MGI

J:8769 Yelick PC, et al., Mouse protamine 2 is synthesized as a precursor whereas mouse protamine 1 is not. Mol Cell Biol. 1987 Jun;7(6):2173-9
J:9141 Johnson PA, et al., Sequence homologies in the mouse protamine 1 and 2 genes. Biochim Biophys Acta. 1988 May 6;950(1):45-53
J:89324 Cho C, et al., Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice. Biol Reprod. 2003 Jul;69(1):211-7
J:241000 Barral S, et al., Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells. Mol Cell. 2017 Apr 06;66(1):89-101.e8
J:307459 Mao S, et al., TDRP deficiency contributes to low sperm motility and is a potential risk factor for male infertility. Am J Transl Res. 2016;8(1):177-87