ID/Version |
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Sequence description from provider |
RecName: Full=Early growth response protein 1; Short=EGR-1;AltName: Full=Nerve growth factor-induced protein A {ECO:0000303|PubMed:1740423}; Short=NGFI-A {ECO:0000303|PubMed:1740423};AltName: Full=Transcription factor Zif268 {ECO:0000303|P | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
533
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:9085
Sukhatme VP, et al., A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988 Apr 8;53(1):37-43
J:9240 Lemaire P, et al., Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4691-5 J:10113 Janssen-Timmen U, et al., Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24; evidence for a common regulatory pathway for immediate-early serum-response genes. Gene. 1989 Aug 15;80(2):325-36 J:26993 Christy BA, et al., A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with zinc finger sequences. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7857-61 J:34254 Gashler AL, et al., A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol Cell Biol. 1993 Aug;13(8):4556-71 J:35132 Lee SL, et al., Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science. 1996 Aug 30;273(5279):1219-21 J:66141 Yan SF, et al., Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med. 2000 Dec;6(12):1355-61 J:93996 Liao Y, et al., Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice. J Biol Chem. 2004 Oct 8;279(41):43107-16 J:99386 Krones-Herzig A, et al., Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Res. 2005 Jun 15;65(12):5133-43 J:267299 Riedel CS, et al., Mice Lacking EGR1 Have Impaired Clock Gene (BMAL1) Oscillation, Locomotor Activity, and Body Temperature. J Mol Neurosci. 2018 Jan;64(1):9-19 J:274077 Tao W, et al., EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription. Sci Rep. 2015 Oct 16;5:15212 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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