Sequence Detail

ID/Version

P08103 Q3UD17 Q0VH03 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Tyrosine-protein kinase HCK; EC=2.7.10.2;AltName: Full=B-cell/myeloid kinase; Short=BMK;AltName: Full=Hematopoietic cell kinase;AltName: Full=Hemopoietic cell kinase;AltName: Full=p56-HCK/p59-HCK;

Provider

SWISS-PROT

Sequence

Polypeptide 524 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hck	hemopoietic cell kinase	53	101	3	17

Sequence references in MGI

J:8946 Holtzman DA, et al., Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. Proc Natl Acad Sci U S A. 1987 Dec;84(23):8325-9
J:16994 Lowell CA, et al., Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15;8(4):387-98
J:19808 Klemsz MJ, et al., Nucleotide sequence of the mouse hck gene. Nucleic Acids Res. 1987 Nov 25;15(22):9600
J:59037 Suen PW, et al., Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J Cell Sci. 1999 Nov;112(Pt 22):4067-78
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110594 Lowell CA, et al., Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol. 1996 May;133(4):895-910
J:124761 Mocsai A, et al., Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol. 1999 Jan 15;162(2):1120-6
J:135267 Xiao W, et al., Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest. 2008 Mar;118(3):924-34
J:140230 Paul R, et al., Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol. 2008 Oct;84(4):1141-50
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:147024 Hong H, et al., The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood. 2007 Oct 1;110(7):2511-9
J:155307 Baruzzi A, et al., c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010 Jan 4;584(1):15-21
J:196121 Cory GO, et al., Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein. J Biol Chem. 2002 Nov 22;277(47):45115-21
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89