Sequence Detail

ID/Version

P08775 Q5F298 (UniProt | EBI)

Last sequence update: 1992-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=DNA-directed RNA polymerase II subunit RPB1; Short=RNA polymerase II subunit B1; EC=2.7.7.6 {ECO:0000250|UniProtKB:P24928};AltName: Full=3'-5' exoribonuclease; EC=3.1.13.- {ECO:0000250|UniProtKB:P24928};AltName: Full=

Provider

SWISS-PROT

Sequence

Polypeptide 1970 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	55	119	3	18

Sequence references in MGI

J:14596 Ahearn JM Jr, et al., Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II. J Biol Chem. 1987 Aug 5;262(22):10695-705
J:123616 Li H, et al., Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells. Mol Cell Biol. 2007 Aug;27(15):5296-305
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:185950 Padmanabhan K, et al., Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012 Aug 3;337(6094):599-602
J:186079 Yuryev A, et al., The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):6975-80
J:200392 Yoh SM, et al., The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. Genes Dev. 2008 Dec 15;22(24):3422-34
J:206171 Schroder S, et al., Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 7;52(3):314-24
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89