Sequence Detail

ID/Version

P09103 Q922C8 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Protein disulfide-isomerase; Short=PDI; EC=5.3.4.1 {ECO:0000250|UniProtKB:P07237};AltName: Full=Cellular thyroid hormone-binding protein;AltName: Full=Endoplasmic reticulum resident protein 59; Short=ER protein 59;

Provider

SWISS-PROT

Sequence

Polypeptide 509 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	P4hb	prolyl 4-hydroxylase, beta polypeptide	59	108	3	22

Sequence references in MGI

J:9055 Gong QH, et al., Nucleotide sequence of a full-length cDNA clone encoding a mouse cellular thyroid hormone binding protein (p55) that is homologous to protein disulfide isomerase and the beta-subunit of prolyl-4-hydroxylase. Nucleic Acids Res. 1988 Feb 11;16(3):1203
J:16067 Mazzarella RA, et al., ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase. J Biol Chem. 1990 Jan 15;265(2):1094-101
J:25202 Helaakoski T, et al., Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4427-31
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:173540 Bi S, et al., Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10650-5
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:300622 Yu J, et al., Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO J. 2020 May 18;39(10):e103841
J:313853 Watanabe K, et al., ILDR2 stabilization is regulated by its interaction with GRP78. Sci Rep. 2021 Apr 16;11(1):8414