Sequence Detail

ID/Version

P09470 Q6GTS2 P22967 (UniProt | EBI)

Last sequence update: 2005-08-30
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Angiotensin-converting enzyme {ECO:0000303|PubMed:2545691}; Short=ACE {ECO:0000303|PubMed:2545691}; EC=3.4.15.1 {ECO:0000269|PubMed:16270063};AltName: Full=Dipeptidyl carboxypeptidase I;AltName: Full=Kininase II {ECO:0000250|

Provider

SWISS-PROT

Sequence

Polypeptide 1312 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ace	angiotensin I converting enzyme	141	109	3	25

Sequence references in MGI

J:9885 Bernstein KE, et al., Mouse angiotensin-converting enzyme is a protein composed of two homologous domains. J Biol Chem. 1989 Jul 15;264(20):11945-51
J:10637 Howard TE, et al., Transcription of testicular angiotensin-converting enzyme (ACE) is initiated within the 12th intron of the somatic ACE gene. Mol Cell Biol. 1990 Aug;10(8):4294-302
J:21460 Bernstein KE, et al., The isolation of angiotensin-converting enzyme cDNA. J Biol Chem. 1988 Aug 15;263(23):11021-4
J:25284 Krege JH, et al., Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 1995 May 11;375(6527):146-8
J:33018 Esther CR Jr, et al., Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest. 1996 May;74(5):953-65
J:42643 Tian B, et al., Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function. Hypertension. 1997 Jul;30(1 Pt 1):128-33
J:46177 Hagaman JR, et al., Angiotensin-converting enzyme and male fertility. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2552-7
J:48697 Ramaraj P, et al., Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme. J Clin Invest. 1998 Jul 15;102(2):371-8
J:63999 Kessler SP, et al., Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme. J Biol Chem. 2000 Aug 25;275(34):26259-64
J:74527 Kessler SP, et al., The germinal isozyme of angiotensin-converting enzyme can substitute for the somatic isozyme in maintaining normal renal structure and functions. J Biol Chem. 2002 Feb 8;277(6):4271-6
J:83777 Kessler SP, et al., Maintenance of normal blood pressure and renal functions are independent effects of angiotensin-converting enzyme. J Biol Chem. 2003 Jun 6;278(23):21105-12
J:89512 Fuchs S, et al., Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice. J Biol Chem. 2004 Apr 16;279(16):15946-53
J:96051 Kondoh G, et al., Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med. 2005 Feb;11(2):160-166
J:128288 Deguchi E, et al., Dipeptidase-inactivated tACE action in vivo: selective inhibition of sperm-zona pellucida binding in the mouse. Biol Reprod. 2007 Nov;77(5):794-802
J:129753 Kessler SP, et al., Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice. FASEB J. 2007 Jan;21(1):156-66
J:134642 Jayasooriya AP, et al., Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6531-6
J:135495 Junot C, et al., RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis. J Pharmacol Exp Ther. 2001 May;297(2):606-11
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:213091 Xiao L, et al., Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling. Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1073-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:322689 Trieu BH, et al., Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid. Science. 2022 Mar 11;375(6585):1177-1182
J:326019 Fuchs S, et al., Male fertility is dependent on dipeptidase activity of testis ACE. Nat Med. 2005 Nov;11(11):140-2