Sequence Detail

ID/Version

P09581 Q3U3P1 Q9DBH9 (UniProt | EBI)

Last sequence update: 2002-05-10
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Macrophage colony-stimulating factor 1 receptor;AltName: Full=CSF-1 receptor; Short=CSF-1-R; Short=CSF-1R; Short=M-CSF-R; EC=2.7.10.1;AltName: Full=Proto-oncogene c-Fms;AltName: CD_antigen=CD115;Flags: Precurs

Provider

SWISS-PROT

Sequence

Polypeptide 977 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Csf1r	colony stimulating factor 1 receptor	139	132	4	24

Sequence references in MGI

J:3980 de Parseval N, et al., Reassessment of the murine c-fms proto-oncogene sequence. Nucleic Acids Res. 1993 Feb 11;21(3):750
J:9174 Rothwell VM, et al., Murine c-fms cDNA: cloning, sequence analysis and retroviral expression. Oncogene Res. 1987 Sep-Oct;1(4):311-24
J:37728 Yue X, et al., Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation. Mol Cell Biol. 1993 Jun;13(6):3191-201
J:58748 Tamura T, et al., FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation. Oncogene. 1999 Nov 11;18(47):6488-95
J:73663 Dai XM, et al., Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood. 2002 Jan 1;99(1):111-20
J:74729 Wilhelmsen K, et al., C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus. Oncogene. 2002 Feb 7;21(7):1079-89
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:109622 Simoncic PD, et al., T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. Mol Cell Biol. 2006 Jun;26(11):4149-60
J:116971 Sakai H, et al., Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts. Bone. 2006 Dec;39(6):1290-301
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:145880 Chen X, et al., Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18267-72
J:164923 Wei S, et al., Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol. 2010 Sep;88(3):495-505
J:177179 Myles GM, et al., Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization. Mol Cell Biol. 1994 Jul;14(7):4843-54
J:177180 van der Geer P, et al., Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. EMBO J. 1993 Dec 15;12(13):5161-72
J:177226 Sampaio NG, et al., Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion. J Cell Sci. 2011 Jun 15;124(Pt 12):2021-31
J:177253 Hiraga T, et al., Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals. Int J Cancer. 2009 Jan 1;124(1):215-22
J:290338 Lenzo JC, et al., Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation. Immunol Cell Biol. 2012 Apr;90(4):429-40
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89