Sequence Detail

ID/Version

P0DMC4 (UniProt | EBI)

Last sequence update: 2014-02-19
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Apelin receptor early endogenous ligand {ECO:0000312|MGI:MGI:3642370};AltName: Full=Protein Elabela {ECO:0000250|UniProtKB:P0DMC2}; Short=ELA {ECO:0000250|UniProtKB:P0DMC2};AltName: Full=Protein Toddler {ECO:0000250|UniProtKB:P0DMC2}

Provider

SWISS-PROT

Sequence

Polypeptide 54 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Apela	apelin receptor early endogenous ligand	33	99	2	35

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:158268 Hassan AS, et al., Expression of two novel transcripts in the mouse definitive endoderm. Gene Expr Patterns. 2010 Feb 12;10(2-3):127-34
J:243623 Freyer L, et al., Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives. Cell Rep. 2017 Aug 29;20(9):2116-2130
J:244834 Ho L, et al., ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017 Aug 18;357(6352):707-713
J:245878 Sharma B, et al., Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts. Dev Cell. 2017 Sep 25;42(6):655-666.e3
J:261072 Sato T, et al., ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. Cardiovasc Res. 2017 Jun 1;113(7):760-769