Sequence Detail

ID/Version

P11103 Q9JLX4 Q9QVQ3 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Poly [ADP-ribose] polymerase 1; Short=PARP-1; EC=2.4.2.30 {ECO:0000250|UniProtKB:P09874};AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 1; Short=ARTD1;AltName: Full=DNA ADP-ribosyltransferase PARP1 {ECO:00

Provider

SWISS-PROT

Sequence

Polypeptide 1013 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Parp1	poly (ADP-ribose) polymerase family, member 1	165	130	3	40

Sequence references in MGI

J:9813 Huppi K, et al., Sequence and organization of the mouse poly (ADP-ribose) polymerase gene. Nucleic Acids Res. 1989 May 11;17(9):3387-401
J:28614 Auer B, et al., On the biological role of the nuclear polymerizing NAD+: protein(ADP-ribosyl) transferase (ADPRT): ADPRT from Dictyostelium discoideum and inactivation of the ADPRT gene in the mouse. Biochimie. 1995;77(6):444-9
J:48490 Borggrefe T, et al., A B-cell-specific DNA recombination complex. J Biol Chem. 1998 Jul 3;273(27):17025-35
J:62269 Sallmann FR, et al., Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks. J Biol Chem. 2000 May 19;275(20):15504-11
J:77259 Schreiber V, et al., Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem. 2002 Jun 21;277(25):23028-36
J:77719 Yu SW, et al., Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002 Jul 12;297(5579):259-63
J:83371 Menissier de Murcia J, et al., Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J. 2003 May 1;22(9):2255-63
J:117094 Andrabi SA, et al., Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18308-13
J:154714 Martin N, et al., PARP-1 transcriptional activity is regulated by sumoylation upon heat shock. EMBO J. 2009 Nov 18;28(22):3534-48
J:173531 Mao Z, et al., SIRT6 promotes DNA repair under stress by activating PARP1. Science. 2011 Jun 17;332(6036):1443-6
J:184115 Rodriguez MI, et al., Poly(ADP-ribose)-dependent regulation of Snail1 protein stability. Oncogene. 2011 Oct 20;30(42):4365-72
J:186001 Wang Y, et al., Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal. 2011;4(167):ra20
J:188026 Erener S, et al., Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-kappaB target genes. Mol Cell. 2012 Apr 27;46(2):200-11
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297184 Huang D, et al., Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. Mol Cell. 2020 Sep 17;79(6):934-949.e14
J:306588 Zhao B, et al., Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability. Cell Stem Cell. 2015 Jun 4;16(6):684-98
J:311744 Kelleher AM, et al., Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2109252118
J:325961 Zada D, et al., Parp1 promotes sleep, which enhances DNA repair in neurons. Mol Cell. 2021 Dec 16;81(24):4979-4993.e7
J:325965 Wang F, et al., Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. Mol Cell. 2022 Jun 2;82(11):2032-2049.e7
J:325974 Posavec Marjanovic M, et al., MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD(+) consumption. Nat Struct Mol Biol. 2017 Nov;24(11):902-910