Sequence Detail

ID/Version

P11438 Q62020 (UniProt | EBI)

Last sequence update: 1990-08-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Lysosome-associated membrane glycoprotein 1; Short=LAMP-1; Short=Lysosome-associated membrane protein 1;AltName: Full=120 kDa lysosomal membrane glycoprotein;AltName: Full=CD107 antigen-like family member A;AltName: Full=LGP-

Provider

SWISS-PROT

Sequence

Polypeptide 406 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lamp1	lysosomal-associated membrane protein 1	61	120	4	15

Sequence references in MGI

J:9216 Chen JW, et al., Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens. J Biol Chem. 1988 Jun 25;263(18):8754-8
J:10609 Granger BL, et al., Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells. J Biol Chem. 1990 Jul 15;265(20):12036-43
J:54567 Andrejewski N, et al., Normal lysosomal morphology and function in LAMP-1-deficient mice. J Biol Chem. 1999 Apr 30;274(18):12692-701
J:92521 Eskelinen EL, et al., Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell. 2004 Jul;15(7):3132-45
J:198895 Demirel O, et al., The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2. J Cell Sci. 2012 Sep 15;125(Pt 18):4230-40
J:202238 Cohnen A, et al., Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage. Blood. 2013 Aug 22;122(8):1411-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:301637 Ng SS, et al., The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nat Immunol. 2020 Oct;21(10):1205-1218