Sequence Detail

ID/Version

P11440 P70337 Q3TI12 (UniProt | EBI)

Last sequence update: 1991-08-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cyclin-dependent kinase 1; Short=CDK1; EC=2.7.11.22 {ECO:0000269|PubMed:36264786}; EC=2.7.11.23 {ECO:0000305|PubMed:2662013};AltName: Full=Cell division control protein 2 homolog {ECO:0000303|PubMed:2208288};AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 297 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdk1	cyclin dependent kinase 1	127	121	3	43

Sequence references in MGI

J:9854 Cisek LJ, et al., Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2. Nature. 1989 Jun 29;339(6227):679-84
J:10753 Th'ng JP, et al., The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product. Cell. 1990 Oct 19;63(2):313-24
J:52474 Jun D, et al., Characterization of the murine cdc2 gene. Mol Cells. 1998 Dec 31;8(6):731-40
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100155 Aleem E, et al., Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat Cell Biol. 2005 Aug;7(8):831-6
J:101521 Han SJ, et al., Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. Curr Biol. 2005 Sep 20;15(18):1670-6
J:124678 Santamaria D, et al., Cdk1 is sufficient to drive the mammalian cell cycle. Nature. 2007 Aug 16;448(7155):811-5
J:171197 Oh JS, et al., Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Science. 2011 Apr 22;332(6028):462-5
J:183245 Mondal G, et al., Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. Mol Cell. 2012 Mar 9;45(5):680-95
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:272927 Inaba H, et al., Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase. Biochem Biophys Res Commun. 2018 Apr 6;498(3):544-550
J:279007 Gomez-H L, et al., The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility. PLoS Genet. 2019 Aug;15(8):e1008316
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:331922 Cheng S, et al., Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment. Science. 2022 Oct 21;378(6617):eabq4835