Sequence Detail

ID/Version

P12023 Q99K32 P97487 P97942 (UniProt | EBI)

Last sequence update: 2003-05-09
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Amyloid-beta precursor protein {ECO:0000250|UniProtKB:P05067};AltName: Full=ABPP; Short=APP;AltName: Full=Alzheimer disease amyloid A4 protein homolog;AltName: Full=Alzheimer disease amyloid protein;AltName: Full=Amyloid precursor pr

Provider

SWISS-PROT

Sequence

Polypeptide 770 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	App	amyloid beta precursor protein	337	123	4	71

Sequence references in MGI

J:994 Izumi R, et al., Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse. Gene. 1992 Mar 15;112(2):189-95
J:2308 De Strooper B, et al., The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. Biochim Biophys Acta. 1991 Dec 2;1129(1):141-3
J:4115 Sola C, et al., Regional distribution of the alternatively spliced isoforms of beta APP RNA transcript in the brain of normal, heterozygous and homozygous weaver mutant mice as revealed by in situ hybridization histochemistry. Brain Res Mol Brain Res. 1993 Mar;17(3-4):340-6
J:9002 Yamada T, et al., Complementary DNA for the mouse homolog of the human amyloid beta protein precursor. Biochem Biophys Res Commun. 1987 Dec 16;149(2):665-71
J:9929 Fukuchi K, et al., Sequence of the protease inhibitor domain of the A4 amyloid protein precursor of Mus domesticus. Nucleic Acids Res. 1989 Jul 11;17(13):5396
J:48365 Yamada T, et al., Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor. Biochem Biophys Res Commun. 1989 Feb 15;158(3):906-12
J:67339 Kumar VB, et al., Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8). Biochem Cell Biol. 2001;79(1):57-67
J:82747 Farris W, et al., Insulin-degrading enzyme regulates the levels of insulin, amyloid beta -protein, and the beta -amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7
J:98747 Cappai R, et al., The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo. J Biol Chem. 2005 Apr 8;280(14):13913-20
J:101417 Andersen OM, et al., Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6
J:103763 Cao Q, et al., Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Mol Cell Biol. 2005 Dec;25(24):10930-9
J:104263 Spoelgen R, et al., Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. J Neurosci. 2006 Jan 11;26(2):418-28
J:113982 Taru H, et al., Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J Biol Chem. 2002 May 31;277(22):20070-8
J:114052 Matsuda S, et al., c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci. 2001 Sep 1;21(17):6597-607
J:142323 Li H, et al., Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode. J Biol Chem. 2008 Oct 3;283(40):27165-78
J:166440 Norstrom EM, et al., Identification of NEEP21 as a ss-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci. 2010 Nov 17;30(46):15677-85
J:188910 Morris SM, et al., Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic. 2001 Feb;2(2):111-23
J:215903 Fernandez-Echevarria C, et al., Abeta promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease. Neuroscience. 2014 Oct 10;278:354-66
J:223355 Suh J, et al., FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness. FASEB J. 2015 Jun;29(6):2628-39
J:225870 Satoh K, et al., ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing. J Biol Chem. 2015 Oct 2;290(40):24152-65
J:229208 Kizuka Y, et al., An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. EMBO Mol Med. 2015 Feb;7(2):175-89
J:230367 Roncarati R, et al., The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7102-7
J:230384 Zambrano N, et al., The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. J Biol Chem. 2001 Jun 8;276(23):19787-92
J:259183 Chen ZC, et al., Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. Sci Signal. 2017 Jul 18;10(488)
J:266459 Das U, et al., Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 7;79(3):447-60
J:268351 Barthet G, et al., Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity. Nat Commun. 2018 Nov 14;9(1):4780
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89