Sequence Detail

ID/Version

P13346 A0A140LIE4 (UniProt | EBI)

Last sequence update: 1990-01-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Protein FosB {ECO:0000305};AltName: Full=FBJ osteosarcoma oncogene B {ECO:0000312|MGI:MGI:95575};AltName: Full=Transcription factor AP-1 subunit FosB {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 338 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fosb	FBJ osteosarcoma oncogene B	33	106	3	13

Sequence references in MGI

J:2957 Lazo PS, et al., Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter. Nucleic Acids Res. 1992 Jan 25;20(2):343-50
J:15672 Zerial M, et al., The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J. 1989 Mar;8(3):805-13
J:34461 Brown JR, et al., A defect in nurturing in mice lacking the immediate early gene fosB. Cell. 1996 Jul 26;86(2):297-309
J:42926 Hiroi N, et al., FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10397-402
J:148647 Solecki W, et al., Role of fosB in behaviours related to morphine reward and spatial memory. Behav Brain Res. 2008 Jul 19;190(2):212-7
J:165057 Vialou V, et al., DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci. 2010 Jun;13(6):745-52
J:193696 Grueter BA, et al., FosB differentially modulates nucleus accumbens direct and indirect pathway function. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1923-8
J:254428 Vierbuchen T, et al., AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection. Mol Cell. 2017 Dec 21;68(6):1067-1082.e12
J:264668 Yutsudo N, et al., fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior. Neuropsychopharmacology. 2013 Apr;38(5):895-906
J:276166 Manning CE, et al., Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning. Neuroscience. 2019 May 15;406:225-233