Sequence Detail

ID/Version

P13405 Q4VA62 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Retinoblastoma-associated protein;AltName: Full=p110-RB1 {ECO:0000303|PubMed:8336704};AltName: Full=pRb; Short=Rb;AltName: Full=pp105;

Provider

SWISS-PROT

Sequence

Polypeptide 921 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rb1	RB transcriptional corepressor 1	153	160	3	63

Sequence references in MGI

J:9980 Bernards R, et al., Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein. Proc Natl Acad Sci U S A. 1989 Sep;86(17):6474-8
J:77935 Chano T, et al., Isolation, characterization and mapping of the mouse and human RB1CC1 genes. Gene. 2002 May 29;291(1-2):29-34
J:99862 Ishii H, et al., Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9655-60
J:108366 Isaac CE, et al., The retinoblastoma protein regulates pericentric heterochromatin. Mol Cell Biol. 2006 May;26(9):3659-71
J:111352 Yoshimoto T, et al., The arginine methyltransferase PRMT2 binds RB and regulates E2F function. Exp Cell Res. 2006 Jul 1;312(11):2040-53
J:163144 Blanchette P, et al., Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. Oncogene. 2001 Sep 6;20(39):5533-7
J:163318 Schaner Tooley CE, et al., NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Nature. 2010 Jul 28;466(7310):1125-1128
J:279973 Zacksenhaus E, et al., A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity. Mol Cell Biol. 1993 Aug;13(8):4588-99
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:352393 Muller L, et al., Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling. Cell Rep. 2023 Jan 31;42(1):112031