Sequence Detail

ID/Version

P13516 Q922I6 (UniProt | EBI)

Last sequence update: 2002-06-06
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Acyl-CoA desaturase 1 {ECO:0000305}; EC=1.14.19.1 {ECO:0000269|PubMed:10899171, ECO:0000269|PubMed:11500518, ECO:0000269|PubMed:11533264, ECO:0000269|PubMed:16275639, ECO:0000269|PubMed:16443825, ECO:0000269|PubMed:26098370};AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 355 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Scd1	stearoyl-Coenzyme A desaturase 1	47	120	4	18

Sequence references in MGI

J:9448 Ntambi JM, et al., Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem. 1988 Nov 25;263(33):17291-300
J:13143 Gates AH, et al., Hereditary absence of sebaceous glands in the mouse. Science. 1965;148:1471-1473
J:58283 Zheng Y, et al., Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse [letter]. Nat Genet. 1999 Nov;23(3):268-70
J:62699 Sundberg JP, et al., Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia. Am J Pathol. 2000 Jun;156(6):2067-75
J:64731 Miyazaki M, et al., The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J Biol Chem. 2000 Sep 29;275(39):30132-8
J:67579 Zheng Y, et al., Scd3-a novel gene of the stearoyl-coa desaturase family with restricted expression in skin. Genomics. 2001 Jan 15;71(2):182-91
J:70344 Miyazaki M, et al., A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J Lipid Res. 2001 Jul;42(7):1018-24
J:71350 Miyazaki M, et al., Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. J Nutr. 2001 Sep;131(9):2260-8
J:78607 Ntambi JM, et al., Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11482-6
J:85276 Miyazaki M, et al., Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem. 2003 Sep 5;278(36):33904-11
J:93033 Lu Y, et al., Scd1( ab-Xyk): a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse. Mol Genet Genomics. 2004 Sep;272(2):129-37
J:93618 Lee SH, et al., Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J Lipid Res. 2004 Sep;45(9):1674-82
J:108167 Miyazaki M, et al., Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. J Lipid Res. 2006 Apr;47(4):700-4
J:120295 Sampath H, et al., Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem. 2007 Jan 26;282(4):2483-93
J:132900 Miyazaki M, et al., Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol. J Biol Chem. 2001 Oct 19;276(42):39455-61
J:209514 Sampath H, et al., Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J Biol Chem. 2014 Jan 31;289(5):2482-8
J:210917 Man WC, et al., Membrane topology of mouse stearoyl-CoA desaturase 1. J Biol Chem. 2006 Jan 13;281(2):1251-60
J:223020 Bai Y, et al., X-ray structure of a mammalian stearoyl-CoA desaturase. Nature. 2015 Aug 13;524(7564):252-6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89