Sequence Detail

ID/Version

P14234 Q8BGM0 Q61404 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Tyrosine-protein kinase Fgr; EC=2.7.10.2;AltName: Full=Proto-oncogene c-Fgr;AltName: Full=p55-Fgr;

Provider

SWISS-PROT

Sequence

Polypeptide 517 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fgr	FGR proto-oncogene, Src family tyrosine kinase	54	98	3	115

Sequence references in MGI

J:10012 Yi TL, et al., Cloning of the murine c-fgr proto-oncogene cDNA and induction of c-fgr expression by proliferation and activation factors in normal bone marrow-derived monocytic cells. Oncogene. 1989 Sep;4(9):1081-7
J:10368 King FJ, et al., Molecular cloning and sequencing of the murine c-fgr gene. Oncogene. 1990 Mar;5(3):337-44
J:16994 Lowell CA, et al., Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15;8(4):387-98
J:94595 Continolo S, et al., The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. Exp Cell Res. 2005 Jan 15;302(2):253-69
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110529 Vines CM, et al., Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 2001 Oct;15(4):507-19
J:110594 Lowell CA, et al., Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol. 1996 May;133(4):895-910
J:114192 Meng F, et al., A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J. 1998 Aug 3;17(15):4391-403
J:131738 Sasanuma H, et al., Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr. Blood. 2006 May 1;107(9):3647-55
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:155307 Baruzzi A, et al., c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010 Jan 4;584(1):15-21
J:177211 Lee JH, et al., The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice. J Immunol. 2011 Aug 15;187(4):1807-15
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89