Sequence Detail

ID/Version

P14404 Q9Z1L8 G3UWT0 (UniProt | EBI)

Last sequence update: 2018-03-28
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase MECOM {ECO:0000305}; EC=2.1.1.367 {ECO:0000269|PubMed:22939622};AltName: Full=Ecotropic virus integration site 1 protein; Short=EVI-1;AltName: Full=MDS1 and EVI1 complex locus protein {ECO:0

Provider

SWISS-PROT

Sequence

Polypeptide 1232 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mecom	MDS1 and EVI1 complex locus	63	120	3	19

Sequence references in MGI

J:32286 Morishita K, et al., Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell. 1988 Sep 9;54(6):831-40
J:42030 Hoyt PR, et al., The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development. Mech Dev. 1997 Jul;65(1-2):55-70
J:51310 Wimmer K, et al., Comparative expression analysis of the antagonistic transcription factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro hematopoietic differentiation. Biochem Biophys Res Commun. 1998 Nov 27;252(3):691-6
J:99332 Yuasa H, et al., Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J. 2005 Jun 1;24(11):1976-87
J:138307 Spensberger D, et al., A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. FEBS Lett. 2008 Aug 6;582(18):2761-7
J:156032 Shimabe M, et al., Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. Oncogene. 2009 Dec 10;28(49):4364-74
J:156086 Matsugi T, et al., Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene. Mol Cell Biol. 1990 Mar;10(3):1259-64
J:269562 Pinheiro I, et al., Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell. 2012 Aug 31;150(5):948-60
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89