ID/Version |
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Sequence description from provider |
RecName: Full=Histone-lysine N-methyltransferase MECOM {ECO:0000305}; EC=2.1.1.367 {ECO:0000269|PubMed:22939622};AltName: Full=Ecotropic virus integration site 1 protein; Short=EVI-1;AltName: Full=MDS1 and EVI1 complex locus protein {ECO:0 | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
1232
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:32286
Morishita K, et al., Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell. 1988 Sep 9;54(6):831-40
J:42030 Hoyt PR, et al., The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development. Mech Dev. 1997 Jul;65(1-2):55-70 J:51310 Wimmer K, et al., Comparative expression analysis of the antagonistic transcription factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro hematopoietic differentiation. Biochem Biophys Res Commun. 1998 Nov 27;252(3):691-6 J:99332 Yuasa H, et al., Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J. 2005 Jun 1;24(11):1976-87 J:138307 Spensberger D, et al., A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. FEBS Lett. 2008 Aug 6;582(18):2761-7 J:156032 Shimabe M, et al., Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. Oncogene. 2009 Dec 10;28(49):4364-74 J:156086 Matsugi T, et al., Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene. Mol Cell Biol. 1990 Mar;10(3):1259-64 J:269562 Pinheiro I, et al., Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell. 2012 Aug 31;150(5):948-60 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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