Sequence Detail

ID/Version

P15116 Q64260 Q6GU11 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Cadherin-2;AltName: Full=Neural cadherin; Short=N-cadherin;AltName: CD_antigen=CD325;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 906 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdh2	cadherin 2	132	226	3	15

Sequence references in MGI

J:2520 Miyatani S, et al., Genomic structure and chromosomal mapping of the mouse N-cadherin gene. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8443-7
J:14761 Miyatani S, et al., Neural cadherin: role in selective cell-cell adhesion. Science. 1989 Aug 11;245(4918):631-5
J:23891 Shapiro L, et al., Structural basis of cell-cell adhesion by cadherins [see comments]. Nature. 1995 Mar 23;374(6520):327-37
J:35398 Munro SB, et al., A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction. Biol Reprod. 1996 Oct;55(4):822-7
J:48283 Tamura K, et al., Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron. 1998 Jun;20(6):1153-63
J:93314 Grossmann KS, et al., Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol. 2004 Nov 11;167(1):149-60
J:153230 Folgueras AR, et al., Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16451-6
J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
J:197851 Hu LY, et al., The kinase domains of obscurin interact with intercellular adhesion proteins. FASEB J. 2013 May;27(5):2001-12
J:213556 Porlan E, et al., MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin. Nat Cell Biol. 2014 Jul;16(7):629-38
J:216456 Vendome J, et al., Structural and energetic determinants of adhesive binding specificity in type I cadherins. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4175-84
J:216499 Wang SH, et al., Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. J Neurosci. 2014 Sep 17;34(38):12745-61
J:227218 Sharma P, et al., Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015;6:8391
J:245244 Harrison OJ, et al., The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure. 2011 Feb 09;19(2):244-56
J:263465 Yasuda S, et al., Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. Neuron. 2007 Nov 8;56(3):456-71
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297286 Wang X, et al., Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro. Sci Rep. 2016 Jan 11;6:19006
J:331911 Halperin D, et al., CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. Nat Commun. 2021 Oct 26;12(1):6187