Sequence Detail

ID/Version

P15208 F8VPU4 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Insulin receptor; Short=IR; EC=2.7.10.1;AltName: CD_antigen=CD220;Contains: RecName: Full=Insulin receptor subunit alpha;Contains: RecName: Full=Insulin receptor subunit beta;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1372 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Insr	insulin receptor	195	123	4	20

Sequence references in MGI

J:10185 Sibley E, et al., Characterization of the mouse insulin receptor gene promoter. Proc Natl Acad Sci U S A. 1989 Dec;86(24):9732-6
J:32474 Flores-Riveros JR, et al., Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit. J Biol Chem. 1989 Dec 25;264(36):21557-72
J:46223 Ribon V, et al., A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol. 1998 Feb;18(2):872-9
J:91027 Ueki K, et al., Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol. 2004 Jun;24(12):5434-46
J:145752 Luan B, et al., Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature. 2009 Feb 26;457(7233):1146-9
J:164596 Ferron M, et al., Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell. 2010 Jul 23;142(2):296-308
J:196641 Galic S, et al., Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. Mol Cell Biol. 2003 Mar;23(6):2096-108
J:204994 Tseng LT, et al., LMBD1 protein serves as a specific adaptor for insulin receptor internalization. J Biol Chem. 2013 Nov 8;288(45):32424-32
J:237133 Schmidt V, et al., SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity. J Clin Invest. 2016 Jul 01;126(7):2706-20
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343785 Benedet PO, et al., CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation. EBioMedicine. 2023 Dec 6;99:104906